Efecto dual de los aminoácidos de cadena ramificada y su relación con la resistencia a la insulina


Resumen

La resistencia a la insulina es una complicación presente en sujetos con obesidad y se ha identificado
como un factor clave en la aparición y progresión de la diabetes mellitus. Numerosos estudios resaltan los
beneficios de una dieta con alto contenido de proteínas tanto para el tratamiento de la obesidad como para la resistencia a la insulina. No obstante, a pesar de dichos beneficios, una dieta hiperproteica se ha relacionado con una peor disfunción metabólica, e incluso empeorando la resistencia a la insulina. Gracias a estudios en metabolómica se ha postulado que los aminoácidos de cadena ramificada pueden estar mediando estos efectos contradictorios de una alta ingesta de proteínas y su relación con la resistencia a la insulina. En la presente revisión narrativa se recopila la evidencia emergente en cuanto al efecto paradójico que pueden desempeñar los aminoácidos de cadena ramificada en la homeostasis del organismo. Diferentes contextos como la presencia de obesidad, patrones dietéticos, origen de proteínas que contengan aminoácidos de cadena ramificada, ejercicio físico, microbiota intestinal, sexo, así como la carga genética, son variables a tener en cuenta para evaluar el rol de estos aminoácidos.


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Cómo citar

Pérez Lagos, F. (2022). Efecto dual de los aminoácidos de cadena ramificada y su relación con la resistencia a la insulina. MLS Health & Nutrition Research, 1(1). Recuperado a partir de https://www.mlsjournals.com/MLS-Health-Nutrition/article/view/964


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