The new coronavirus has had a catastrophic toll around the world on physical and mental health. In this article, we focus on the psychosocial impact among students in Uruguay, a country relatively protected from the pandemic during 2020. Our study had three main objectives: 1) describe the impact in detail; 2) identify the relationships between the different dimensions and; 3) highlight the determinants of mental health. We designed a multidimensional questionnaire to investigate the perceived impact of students. The questionnaire was administered online to 144 Uruguayan university students while the university was closed. Between 38 and 66% of the students indicated an increase in signs of anxiety, depression or sleep disturbances. Regardless of other related factors, increased substance use, deterioration in social relationships, negative impact of school closings, and personal financial concerns accounted for 41% of the variation in mental health. The findings are discussed in terms of their implications for public health and future directions of research on the effects of the pandemic on mental health.
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