El consumo de alcohol es un fenómeno presente entre estudiantes universitarios que puede estar asociados con diferentes factores psicológicos. El objetivo de este estudio fue analizar la relación entre el consumo de alcohol, el estrés percibido y la inflexibilidad psicológica en tres grupos independientes. Los datos se recolectaron mediante cuestionarios en línea y fueron administrados a una muestra no probabilística de 293 estudiantes universitarios de modalidad abierta y a distancia. Los instrumentos utilizados fueron la Escala de Estrés Percibido (PSS-10) y el Cuestionario de Aceptación y Compromiso-II (AAQ-II). Los resultados muestran que existe una relación estadísticamente significativa entre el estrés percibido, la inflexibilidad psicológica y el consumo de alcohol (p<0,001). A mayores niveles de las variables transdiagnósticas (estrés percibido e inflexibilidad psicológica), se observaron mayores niveles de consumo de alcohol. Estos resultados sugieren que el alcohol puede actuar como una estrategia de afrontamiento desadaptativa, aumentando el riesgo de dependencia. Los resultados coinciden con investigaciones previas, pero contrastan con algunos estudios, posiblemente debido a factores sociodemográficos. Las intervenciones dirigidas al manejo del estrés y la flexibilidad psicológica son cruciales. Las limitaciones incluyen el diseño transversal y el uso de cuestionarios de autoinforme, lo que limita las inferencias causales. Los hallazgos enfatizan los factores transdiagnósticos en el consumo de alcohol, lo que justifica una mayor investigación para fundamentar las estrategias de prevención.
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